Bumetanide

Definition

Bumetanide is a potent loop diuretic used to treat edema associated with heart failure, liver disease, and renal impairment. It works by inhibiting the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle.

5 Must Know Facts For Your Next Test

1. Bumetanide is more potent than furosemide on a per milligram basis.
2. It increases the excretion of sodium, chloride, and water.
3. Bumetanide can lead to electrolyte imbalances such as hypokalemia and hyponatremia.
4. It has a rapid onset of action, typically within 30-60 minutes when taken orally.
5. Common side effects include dizziness, dehydration, and muscle cramps.

Review Questions

• What is the primary mechanism of action for Bumetanide?
• Why might Bumetanide be prescribed over other diuretics?
• List two common side effects associated with Bumetanide use.

Related terms

Furosemide: A less potent loop diuretic also used to treat edema and heart failure.

Hypokalemia: A condition where there is a lower-than-normal level of potassium in the blood, often caused by diuretics.

Na-K-2Cl Symporter: A protein that facilitates the reabsorption of sodium, potassium, and chloride ions in the nephron's thick ascending limb.