Bempedoic acid

Definition

Bempedoic acid is a lipid-lowering drug that inhibits adenosine triphosphate-citrate lyase (ACL), an enzyme involved in cholesterol synthesis. It is used to reduce low-density lipoprotein cholesterol (LDL-C) levels in patients with hypercholesterolemia.

5 Must Know Facts For Your Next Test

1. Bempedoic acid works by inhibiting the enzyme ATP-citrate lyase, which is upstream of HMG-CoA reductase in the cholesterol biosynthesis pathway.
2. It is often prescribed as an adjunct therapy to diet and other lipid-lowering treatments, particularly statins.
3. Bempedoic acid has been shown to lower LDL-C levels by approximately 15-20% when used alone and up to 30% when used in combination with ezetimibe.
4. The drug is administered orally, usually once daily, and can be taken with or without food.
5. Common side effects include upper respiratory tract infections, muscle spasms, back pain, abdominal pain, and elevated liver enzymes.

Review Questions

• What enzyme does bempedoic acid inhibit to lower cholesterol levels?
• How effective is bempedoic acid in lowering LDL-C when combined with ezetimibe?
• What are some common side effects associated with bempedoic acid?

Related terms

Statins: A class of drugs that reduce cholesterol levels by inhibiting HMG-CoA reductase.

Ezetimibe: A medication used to lower plasma cholesterol levels by inhibiting the absorption of cholesterol from the small intestine.

Hypercholesterolemia: A condition characterized by high levels of cholesterol in the blood, increasing the risk of cardiovascular diseases.