Argatroban

Definition

Argatroban is a direct thrombin inhibitor used as an anticoagulant. It is primarily administered intravenously to prevent or treat thrombosis in patients with heparin-induced thrombocytopenia (HIT).

5 Must Know Facts For Your Next Test

1. Argatroban binds directly to thrombin, inhibiting its activity and preventing clot formation.
2. It is used in patients who cannot be treated with heparin due to heparin-induced thrombocytopenia (HIT).
3. Argatroban has a short half-life and requires continuous intravenous infusion for effective anticoagulation.
4. The drug does not require a binding protein, unlike some other anticoagulants like warfarin.
5. Monitoring of Argatroban therapy is typically done using activated partial thromboplastin time (aPTT).

Review Questions

• What mechanism does Argatroban use to exert its anticoagulant effect?
• In which clinical condition is Argatroban commonly used as an alternative to heparin?
• How is the effectiveness of Argatroban therapy monitored?

Related terms

Heparin-Induced Thrombocytopenia (HIT): A complication of heparin therapy leading to low platelet count and increased risk of thrombosis.

Warfarin: An oral anticoagulant that inhibits vitamin K-dependent clotting factors.

Activated Partial Thromboplastin Time (aPTT): A laboratory test used to monitor the efficacy of certain anticoagulants, including Argatroban.