Angiomax

Definition

Angiomax (bivalirudin) is a direct thrombin inhibitor used to prevent blood clots in patients undergoing certain cardiac procedures. It works by binding to thrombin, preventing the conversion of fibrinogen to fibrin.

5 Must Know Facts For Your Next Test

1. Angiomax is primarily used during percutaneous coronary interventions (PCI).
2. It has a rapid onset and short half-life, making it easily controllable.
3. Angiomax does not require routine monitoring of coagulation parameters like INR.
4. It is administered intravenously and dosage adjustments are necessary for patients with renal impairment.
5. The major side effect of Angiomax is bleeding, similar to other anticoagulants.

Review Questions

• What is the main clinical use of Angiomax?
• Why does Angiomax not require routine monitoring like other anticoagulants?
• What is a major side effect associated with the use of Angiomax?

Related terms

Heparin: An anticoagulant that prevents clot formation by inhibiting thrombin and factor Xa.

Warfarin: An oral anticoagulant that acts by inhibiting vitamin K-dependent clotting factors.

Thrombolytics: Drugs that dissolve blood clots by breaking down fibrin threads within the clot.