Amiloride

Definition

Amiloride is a potassium-sparing diuretic that inhibits sodium reabsorption in the kidneys. It is commonly used to treat hypertension and congestive heart failure.

5 Must Know Facts For Your Next Test

1. Amiloride acts on the distal convoluted tubule and collecting duct of the nephron.
2. It prevents potassium loss by blocking sodium channels, thus reducing sodium-potassium exchange.
3. Common side effects include hyperkalemia, nausea, and dizziness.
4. Amiloride is often used in combination with other diuretics like thiazides to balance potassium levels.
5. It is contraindicated in patients with hyperkalemia or those taking potassium supplements.

Review Questions

• What part of the nephron does Amiloride act on?
• How does Amiloride help prevent hypokalemia?
• Why might Amiloride be contraindicated for some patients?

Related terms

Hydrochlorothiazide: A thiazide diuretic that helps reduce fluid accumulation by inhibiting sodium reabsorption.

Spironolactone: Another potassium-sparing diuretic that works as an aldosterone antagonist.

Furosemide: A loop diuretic used to treat edema associated with congestive heart failure and renal disease.