Aldosterone antagonists

Definition

Aldosterone antagonists are a class of medications that block the effects of aldosterone, a hormone responsible for sodium and water retention. They are commonly used to treat heart failure and hypertension by promoting the excretion of sodium and water, reducing blood volume and pressure.

5 Must Know Facts For Your Next Test

1. Aldosterone antagonists help manage heart failure by reducing fluid overload.
2. Common examples include spironolactone and eplerenone.
3. They can cause hyperkalemia due to potassium retention.
4. Aldosterone antagonists improve survival rates in patients with severe heart failure.
5. These drugs may be contraindicated in patients with renal impairment.

Review Questions

• What is the primary function of aldosterone antagonists in treating heart failure?
• Name two common aldosterone antagonists used in clinical practice.
• What is a potential side effect of using aldosterone antagonists?

Related terms

Renin-Angiotensin-Aldosterone System (RAAS): A hormone system regulating blood pressure and fluid balance.

Spironolactone: An aldosterone antagonist used to treat heart failure, hypertension, and edema.

Hyperkalemia: A condition characterized by elevated levels of potassium in the blood, which can be a side effect of aldosterone antagonists.