Adalimumab

Definition

Adalimumab is a monoclonal antibody used as an immunosuppressant to treat autoimmune conditions like rheumatoid arthritis and psoriasis. It works by inhibiting tumor necrosis factor-alpha (TNF-alpha), a substance in the body that causes inflammation.

5 Must Know Facts For Your Next Test

1. Adalimumab is administered via subcutaneous injection.
2. It is commonly used to treat conditions such as rheumatoid arthritis, Crohn's disease, and plaque psoriasis.
3. Adalimumab can increase the risk of serious infections due to its immunosuppressive effects.
4. Patients should be screened for latent tuberculosis before starting treatment with Adalimumab.
5. Common side effects include injection site reactions, headache, and rash.

Review Questions

• What mechanism does Adalimumab use to reduce inflammation in autoimmune diseases?
• Name at least two conditions that Adalimumab is used to treat.
• Why must patients be screened for tuberculosis before starting Adalimumab?

Related terms

Infliximab: Another TNF-alpha inhibitor used to treat similar autoimmune diseases.

Etanercept: A biologic drug that also inhibits TNF-alpha but has a different structure compared to Adalimumab.

Methotrexate: An immunosuppressant often used in combination with biologics like Adalimumab for treating rheumatoid arthritis.