Activase

Definition

Activase, also known as alteplase, is a thrombolytic drug used to dissolve blood clots in patients experiencing acute myocardial infarction, ischemic stroke, or pulmonary embolism. It works by converting plasminogen to plasmin, an enzyme that breaks down fibrin clots.

5 Must Know Facts For Your Next Test

1. Activase is administered intravenously and must be given within a specific time window after the onset of symptoms for maximum effectiveness.
2. The drug has a short half-life of about 5 minutes but its effects can last up to an hour due to the activation of plasminogen.
3. It is contraindicated in patients with active internal bleeding, recent surgery, or severe uncontrolled hypertension.
4. Common side effects include bleeding complications such as intracranial hemorrhage and gastrointestinal bleeding.
5. Monitoring of coagulation parameters and neurological status is crucial during Activase therapy.

Review Questions

• What is the primary mechanism of action for Activase?
• Within what time frame must Activase be administered for treatment of ischemic stroke?
• List two contraindications for the use of Activase.

Related terms

Thrombolytics: A class of drugs that break down blood clots by dissolving fibrin.

Anticoagulants: Medications that prevent new clots from forming but do not dissolve existing ones.

Plasminogen: A precursor protein that is converted into plasmin by thrombolytic agents like Activase.