Hofmann rearrangement

Definition

Hofmann rearrangement is a chemical reaction that converts primary amides into primary amines with one fewer carbon atom, using bromine and a base. This process involves the rearrangement of the molecular structure and elimination of a carbon unit in the form of carbon dioxide.

Related terms

Primary amides: Organic compounds where the carbonyl group (C=O) is attached to a nitrogen atom and one hydrogen atom.

Primary amines: Nitrogen-containing organic compounds characterized by having the nitrogen atom bonded to one alkyl or aryl group.

Carbon dioxide (CO2): A colorless, odorless gas produced by burning carbon and organic compounds and by respiration, expelled from the body during the Hofmann rearrangement