Anti periplanar

Definition

Anti periplanar configuration describes the spatial arrangement in a molecule where two substituents are positioned opposite to each other across a single bond, typically in a linear fashion. This configuration is particularly crucial for the E2 elimination reaction mechanism in organic chemistry, enabling the efficient removal of a hydrogen and a leaving group to form a double bond.

Related terms

E2 Elimination: A bimolecular elimination reaction where both the base and substrate participate in the rate-determining step, leading to the formation of a double bond.

Nucleophilic Substitution: A fundamental chemical process where an electron-rich nucleophile selectively replaces a leaving group attached to carbon.

Deuterium Isotope Effect: The effect observed on the rate of chemical reactions when an atom of hydrogen is replaced by its isotope deuterium, often used to investigate reaction mechanisms