Acetoacetic ester synthesis

Definition

Acetoacetic ester synthesis is a method in organic chemistry for synthesizing substituted ketones by the alkylation of acetoacetic ester, followed by hydrolysis and decarboxylation. It utilizes the enol or enolate form of the ester to introduce new alkyl groups at the alpha position of the original ketone.

Related terms

Enolate Ion: An ion formed by deprotonation at the alpha carbon of carbonyl compounds, essential for nucleophilic attacks in various organic reactions.

Alkylation: The process of adding an alkyl group to a molecule, often used in creating more complex molecules from simpler ones in organic synthesis.

Decarboxylation: A chemical reaction that removes a carboxyl group and releases carbon dioxide, often used in organic chemistry to modify acids into their corresponding hydrocarbons