Tzanck testing

Definition

Tzanck testing is a diagnostic procedure used to identify certain viral infections, primarily herpes simplex and varicella-zoster viruses. It involves scraping the base of a vesicle or ulcer to obtain cells for microscopic examination.

5 Must Know Facts For Your Next Test

1. Tzanck testing helps diagnose herpes simplex and varicella-zoster virus infections.
2. The test involves scraping the base of a lesion to collect cells for analysis.
3. Multinucleated giant cells seen under the microscope are indicative of a positive Tzanck test.
4. A negative Tzanck test does not rule out infection; further tests like PCR may be needed.
5. Tzanck testing is less commonly used today due to more advanced methods like PCR.

Review Questions

• What types of viral infections can be diagnosed using Tzanck testing?
• What cellular feature is typically looked for in a positive Tzanck test?
• Why might additional tests be necessary even if the Tzanck test is negative?

Related terms

Herpes Simplex Virus: A virus causing contagious sores, most often around the mouth or on the genitals.

Varicella-Zoster Virus: The virus responsible for chickenpox and shingles.

Polymerase Chain Reaction (PCR): A method used to amplify DNA sequences for various diagnostic applications, including viral detection.