Iron sequestration

Definition

Iron sequestration is the process by which iron is bound and stored in a manner that makes it unavailable for pathogens. It is a defensive response by the body to limit the availability of iron, which is crucial for bacterial growth and proliferation.

5 Must Know Facts For Your Next Test

1. Iron sequestration is often mediated by proteins such as ferritin and lactoferrin.
2. During chronic inflammation, increased levels of hepcidin play a significant role in iron sequestration.
3. Iron sequestration can lead to anemia of chronic disease due to reduced iron availability for erythropoiesis.
4. Macrophages play a key role in sequestering iron from hemoglobin during red blood cell recycling.
5. Iron sequestration helps protect against infections but can complicate nutritional management in patients with chronic illnesses.

Review Questions

• What role does hepcidin play in iron sequestration during chronic inflammation?
• How does iron sequestration contribute to anemia of chronic disease?
• Which proteins are primarily involved in the process of iron sequestration?

Related terms

Hepcidin: A liver-produced hormone that regulates iron balance by inhibiting intestinal absorption and promoting storage.

Ferritin: A protein complex that stores iron intracellularly and releases it in a controlled fashion.

Anemia of Chronic Disease: A type of anemia seen in chronic infection, inflammatory diseases, or malignancy, characterized by impaired utilization of stored iron.