Iron-restricted erythropoiesis

Definition

Iron-restricted erythropoiesis is a condition where the production of red blood cells is limited due to insufficient iron. This can occur despite normal or increased iron stores in the body, often due to impaired iron mobilization.

5 Must Know Facts For Your Next Test

1. Iron-restricted erythropoiesis can occur in chronic diseases such as chronic kidney disease and inflammatory disorders.
2. It often leads to anemia, characterized by low hemoglobin levels and reduced oxygen-carrying capacity of the blood.
3. Inflammation increases hepcidin levels, a hormone that inhibits iron absorption and release from stores.
4. Diagnosis may involve laboratory tests showing low serum iron, high ferritin (an indicator of inflammation), and high transferrin saturation.
5. Treatment strategies include addressing the underlying cause of inflammation, using intravenous iron therapy, or administering erythropoiesis-stimulating agents (ESAs).

Review Questions

• What are common chronic conditions associated with iron-restricted erythropoiesis?
• How does inflammation contribute to iron-restricted erythropoiesis?
• What are some treatment options for managing iron-restricted erythropoiesis?

Related terms

Anemia: A condition where there is a deficiency in red blood cells or hemoglobin, leading to fatigue and weakness.

Hepcidin: A hormone produced by the liver that regulates iron balance by inhibiting intestinal absorption and release from macrophages.

Erythropoiesis-Stimulating Agents (ESAs): Medications used to stimulate the production of red blood cells in patients with certain types of anemia.