Gonadotropin-releasing hormone agonists

Definition

Gonadotropin-releasing hormone agonists (GnRH agonists) are synthetic peptides that mimic the natural GnRH produced by the hypothalamus. They are often used to manage hormonal conditions, including certain cancers and reproductive health issues.

5 Must Know Facts For Your Next Test

1. GnRH agonists initially increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), but continuous use leads to a decrease in these hormones.
2. They are commonly used in the treatment of prostate cancer, endometriosis, and precocious puberty.
3. Nutritional considerations include monitoring bone density as long-term use can lead to decreased bone mineral density due to lowered sex hormone levels.
4. Patients on GnRH agonists may require calcium and vitamin D supplementation to support musculoskeletal health.
5. Common side effects include hot flashes, mood changes, and decreased libido, which should be managed through supportive nutritional strategies.

Review Questions

• What effect do GnRH agonists have on LH and FSH levels with continuous use?
• Why is it important to monitor bone density in patients using GnRH agonists?
• What dietary supplements might be recommended for someone undergoing treatment with GnRH agonists?

Related terms

Luteinizing Hormone (LH): A hormone produced by the anterior pituitary gland that is crucial for reproductive health.

Follicle-Stimulating Hormone (FSH): A hormone involved in the maturation of ovarian follicles in women and spermatogenesis in men.

Hypothalamus: A region of the brain that produces hormones regulating many bodily functions, including hunger, thirst, sleep, and emotional activity.