Enterohepatic circulation

Definition

Enterohepatic circulation is the process where bile acids and other substances are recycled from the intestine to the liver. It plays a crucial role in digestion and nutrient absorption, particularly fats.

5 Must Know Facts For Your Next Test

1. Bile acids are synthesized in the liver, stored in the gallbladder, and released into the small intestine.
2. Approximately 95% of bile acids are reabsorbed in the ileum and returned to the liver via portal circulation.
3. Enterohepatic circulation helps maintain cholesterol balance by recycling bile acids.
4. Certain drugs and hormones can undergo enterohepatic recirculation, affecting their duration of action.
5. Interruptions in enterohepatic circulation can lead to malabsorption of fat-soluble vitamins (A, D, E, K).

Review Questions

• What role does enterohepatic circulation play in fat digestion?
• How does enterohepatic circulation affect cholesterol levels?
• Why is it important for certain drugs to undergo enterohepatic recirculation?

Related terms

Bile Acids: Substances produced by the liver that aid in the digestion and absorption of fats.

Portal Circulation: The system of blood vessels that carries blood from the gastrointestinal tract to the liver.

Fat-Soluble Vitamins: Vitamins (A, D, E, K) that dissolve in fats and oils and are stored in body tissues.