Beta-amyloid aggregation

Definition

Beta-amyloid aggregation is the process where beta-amyloid proteins clump together to form plaques in the brain. These plaques are associated with the neurodegenerative changes seen in Alzheimer's disease.

5 Must Know Facts For Your Next Test

1. Beta-amyloid aggregation disrupts cell-to-cell communication and activates immune responses leading to inflammation.
2. Nutritional factors, such as dietary fats and antioxidants, can influence beta-amyloid aggregation.
3. High levels of beta-amyloid plaques are a hallmark of Alzheimer's disease pathology.
4. Omega-3 fatty acids have been shown to potentially reduce beta-amyloid plaque formation.
5. Insulin resistance and type 2 diabetes may increase the risk of beta-amyloid accumulation.

Review Questions

• How does beta-amyloid aggregation affect neuronal function?
• What nutritional factors can influence the formation of beta-amyloid plaques?
• Why is beta-amyloid aggregation significant in the context of Alzheimer's disease?

Related terms

Neuroinflammation: Inflammatory response within the brain or spinal cord often associated with neurodegenerative diseases.

Oxidative Stress: An imbalance between free radicals and antioxidants in your body that can lead to cell and tissue damage.

Alzheimer's Disease: A progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and personality changes.