Amiodarone

Definition

Amiodarone is an antiarrhythmic medication used to treat and prevent various types of cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. It works by prolonging the action potential and refractory period in heart tissues.

5 Must Know Facts For Your Next Test

1. Amiodarone has a high iodine content, which can influence thyroid function and lead to either hyperthyroidism or hypothyroidism.
2. Due to its potential impact on thyroid health, regular monitoring of thyroid function tests (TFTs) is recommended for patients on long-term amiodarone therapy.
3. The bioavailability of amiodarone can be affected by dietary factors; a high-fat meal can increase its absorption.
4. Amiodarone has a long half-life, leading to prolonged effects even after discontinuation, which necessitates careful management of any nutritional interventions related to endocrine health.
5. Nutritional status can affect the metabolism and excretion of amiodarone; deficiencies in certain nutrients like selenium may exacerbate its side effects.

Review Questions

• How does amiodarone influence thyroid function?
• Why is it important to monitor thyroid function tests (TFTs) in patients taking amiodarone?
• What dietary factors might influence the absorption and metabolism of amiodarone?

Related terms

Antiarrhythmic Medication: Drugs used to treat abnormal heart rhythms.

Thyroid Function Tests (TFTs): Blood tests that measure how well the thyroid gland is working.

Hyperthyroidism: A condition where the thyroid gland produces too much thyroid hormone.