Winterbottom’s sign

Definition

Winterbottom’s sign is the swelling of lymph nodes in the posterior cervical region, commonly associated with African trypanosomiasis (sleeping sickness). It serves as a clinical indicator of the early stage of this parasitic infection.

5 Must Know Facts For Your Next Test

1. Winterbottom's sign is named after British physician Thomas Masterman Winterbottom.
2. It is most commonly seen in patients infected with Trypanosoma brucei gambiense.
3. The swollen lymph nodes are typically painless and located at the back of the neck.
4. Winterbottom’s sign indicates the hemolymphatic stage of African trypanosomiasis.
5. Early diagnosis and treatment are crucial to prevent progression to the neurological phase, which can be fatal.

Review Questions

• What parasitic infection is Winterbottom's sign associated with?
• Where are the swollen lymph nodes located in Winterbottom's sign?
• Why is early detection of Winterbottom's sign important?

Related terms

African trypanosomiasis: A parasitic disease also known as sleeping sickness, caused by Trypanosoma brucei.

Trypanosoma brucei gambiense: The subspecies of Trypanosoma responsible for West African sleeping sickness.

Hemolymphatic stage: The early stage of African trypanosomiasis where parasites spread through blood and lymphatic system.