Vincristine

Definition

Vincristine is a chemotherapy medication used to treat various types of cancer by inhibiting the growth of cancer cells. It specifically interferes with the formation of microtubules, which are essential for cell division.

5 Must Know Facts For Your Next Test

1. Vincristine is derived from the periwinkle plant, Catharanthus roseus.
2. It works by binding to tubulin, preventing microtubule assembly and thereby halting mitosis.
3. Vincristine is administered intravenously and is commonly part of combination chemotherapy regimens.
4. Common side effects include peripheral neuropathy, constipation, and hair loss.
5. Due to its mode of action, vincristine can affect both cancerous and normal rapidly dividing cells.

Review Questions

• What is the primary mechanism by which vincristine inhibits cancer cell growth?
• Identify at least two common side effects associated with vincristine use.
• How is vincristine typically administered in clinical settings?

Related terms

Chemotherapy: A type of cancer treatment that uses drugs to kill or inhibit the growth of cancer cells.

Microtubules: Cylindrical structures made of tubulin proteins that are essential for cell division.

Peripheral Neuropathy: A condition resulting from damage to the peripheral nerves often causing weakness, numbness, and pain.