TSH-receptor antibody

Definition

TSH-receptor antibodies are autoantibodies that target the thyroid-stimulating hormone receptor, often leading to hyperthyroidism. They play a key role in autoimmune thyroid diseases such as Graves' disease.

5 Must Know Facts For Your Next Test

1. TSH-receptor antibodies stimulate the thyroid gland to produce excessive thyroid hormones, causing hyperthyroidism.
2. These antibodies are primarily associated with Graves' disease, an autoimmune disorder.
3. The presence of TSH-receptor antibodies is used as a diagnostic marker for Graves' disease.
4. TSH-receptor antibodies can cross the placenta and affect fetal thyroid function during pregnancy.
5. Management of Graves' disease may involve anti-thyroid medications, radioactive iodine therapy, or surgery.

Review Questions

• What is the primary function of TSH-receptor antibodies in autoimmune thyroid diseases?
• Which autoimmune disorder is most commonly associated with TSH-receptor antibodies?
• How can TSH-receptor antibodies affect pregnancy?

Related terms

Graves' Disease: An autoimmune disorder where TSH-receptor antibodies cause hyperthyroidism.

Hyperthyroidism: A condition where the thyroid gland produces excess thyroid hormones.

Autoantibody: An antibody produced by the immune system that mistakenly targets and attacks the body's own tissues.