Triclosan

Definition

Triclosan is an antibacterial and antifungal agent commonly used in consumer products like soaps, toothpaste, and disinfectants. It disrupts microbial cell membranes and inhibits fatty acid synthesis.

5 Must Know Facts For Your Next Test

1. Triclosan targets the enzyme enoyl-acyl carrier protein reductase (ENR) in bacteria, inhibiting fatty acid synthesis essential for cell membrane production.
2. It has been shown to contribute to antibiotic resistance by promoting cross-resistance to other antimicrobials.
3. The use of triclosan in household products has been restricted or banned in several countries due to environmental and health concerns.
4. Triclosan can persist in the environment, leading to potential bioaccumulation and adverse effects on aquatic ecosystems.
5. Studies have found that triclosan exposure can disrupt hormonal function, particularly affecting thyroid hormone metabolism.

Review Questions

• What enzymatic target does triclosan inhibit in bacteria?
• Why has the use of triclosan in consumer products been restricted or banned in some countries?
• How does triclosan contribute to antibiotic resistance?

Related terms

Antimicrobial Agent: A substance that kills or inhibits the growth of microorganisms.

Enoyl-acyl Carrier Protein Reductase (ENR): An enzyme involved in bacterial fatty acid synthesis targeted by triclosan.

Bioaccumulation: The accumulation of substances, such as pesticides or chemicals, in an organism over time.