Terbinafine

Definition

Terbinafine is an antifungal medication primarily used to treat fungal infections of the skin and nails. It works by inhibiting the enzyme squalene epoxidase, leading to a deficiency in ergosterol, an essential component of fungal cell membranes.

5 Must Know Facts For Your Next Test

1. Terbinafine is effective against dermatophytes, which cause common skin and nail infections such as athlete's foot and ringworm.
2. The drug can be administered orally or topically, depending on the type and severity of the infection.
3. Terbinafine accumulates in keratinous tissues like skin, hair, and nails, which makes it particularly effective for treating dermatophytic infections.
4. Common side effects include gastrointestinal issues, headaches, and changes in taste perception when taken orally.
5. Due to its mechanism of action on squalene epoxidase, terbinafine specifically disrupts fungal cell membrane synthesis without affecting human cells.

Review Questions

• What enzyme does terbinafine inhibit to exert its antifungal effects?
• Which types of infections is terbinafine most commonly used to treat?
• What are some common side effects associated with oral administration of terbinafine?

Related terms

Squalene Epoxidase: An enzyme targeted by terbinafine that is crucial for ergosterol synthesis in fungi.

Dermatophytes: A group of fungi that cause infections in keratinized tissues such as skin, hair, and nails.

Ergosterol: A key component of fungal cell membranes whose synthesis is inhibited by drugs like terbinafine.