Polyhexamethylene biguanide

Definition

Polyhexamethylene biguanide (PHMB) is a polymeric antimicrobial agent used for its broad-spectrum activity against bacteria, fungi, and viruses. It is commonly employed in medical and cosmetic applications, including wound care and contact lens solutions.

5 Must Know Facts For Your Next Test

1. PHMB has broad-spectrum antimicrobial properties effective against bacteria, fungi, and viruses.
2. It disrupts microbial cell membranes by binding to the phospholipids in the lipid bilayer.
3. PHMB is commonly used in wound dressings to prevent infection and promote healing.
4. It is also utilized in contact lens solutions to disinfect lenses and prevent eye infections.
5. Studies have shown that PHMB can be effective against biofilms, which are complex communities of microorganisms resistant to standard treatments.

Review Questions

• What types of microorganisms does PHMB effectively target?
• How does PHMB disrupt microbial cell membranes?
• In what common medical applications might you find PHMB being used?

Related terms

Biofilm: A structured community of microorganisms encapsulated within a self-produced matrix, adherent to an inert or living surface.

Antimicrobial Agent: A substance that kills or inhibits the growth of microorganisms such as bacteria, fungi, or viruses.

Contact Lens Solution: A liquid solution designed for disinfecting and storing contact lenses to prevent eye infections.