Mismatch repair is a cellular process that corrects errors introduced during DNA replication. It increases the fidelity of DNA replication by recognizing and repairing mismatched nucleotides.
5 Must Know Facts For Your Next Test
Mismatch repair involves proteins that detect and remove mismatched bases, followed by resynthesis of the correct sequence.
The key proteins in mismatch repair include MutS, MutL, and MutH in prokaryotes.
Defects in mismatch repair can lead to microsatellite instability and are associated with certain types of cancer.
Methylation of the parent strand helps differentiate between the old and new strands during mismatch repair in bacteria.
In eukaryotes, MSH2, MLH1, PMS2, and other homologs carry out similar functions as their prokaryotic counterparts.