Lupus

Definition

Lupus is a chronic autoimmune disease where the immune system attacks healthy tissues, causing widespread inflammation and damage. It can affect various organs, including the skin, joints, kidneys, brain, and other parts of the body.

5 Must Know Facts For Your Next Test

1. Lupus involves the production of autoantibodies that target the body's own cells and tissues.
2. The exact cause of lupus is unknown, but it is believed to involve genetic, environmental, and hormonal factors.
3. Common symptoms of lupus include fatigue, joint pain, skin rashes (especially a butterfly-shaped rash on the face), and fever.
4. Diagnosis often requires a combination of clinical evaluation and laboratory tests such as antinuclear antibody (ANA) testing.
5. Treatment typically includes immunosuppressive drugs to reduce inflammation and prevent flare-ups.

Review Questions

• What types of tissues and organs can be affected by lupus?
• Which diagnostic test is commonly used to detect lupus-related autoantibodies?
• What are some common symptoms associated with lupus?

Related terms

Autoimmunity: A condition where the immune system mistakenly attacks the body's own cells.

Antinuclear antibody (ANA): Antibodies that target substances found in the nucleus of cells; commonly present in autoimmune diseases like lupus.

Immunosuppressive drugs: Medications that inhibit or prevent activity of the immune system; used in treating autoimmune diseases.