Human rabies immune globulin

Definition

Human rabies immune globulin (HRIG) is a medication used for passive immunization against the rabies virus. It is administered after potential exposure to provide immediate but temporary protection until the rabies vaccine can stimulate active immunity.

5 Must Know Facts For Your Next Test

1. HRIG should be administered as soon as possible after exposure to the rabies virus.
2. The administration of HRIG involves injecting it directly into and around the wound site, if possible.
3. HRIG provides passive immunity by supplying ready-made antibodies that neutralize the rabies virus.
4. It is often given in conjunction with the rabies vaccine, which promotes long-term active immunity.
5. HRIG is derived from plasma donated by individuals who have been immunized against rabies.

Review Questions

• What is the primary purpose of administering human rabies immune globulin?
• Why must HRIG be given in conjunction with the rabies vaccine?
• How does HRIG provide immediate protection against the rabies virus?

Related terms

Rabies Vaccine: A series of injections that stimulate active immunity against the rabies virus.

Passive Immunization: The administration of pre-formed antibodies to provide immediate protection against an infection.

Active Immunization: The process by which exposure to an antigen triggers the immune system to produce its own antibodies and memory cells for long-term protection.