Folinic acid

Definition

Folinic acid, also known as leucovorin, is a form of folate used in the body to aid DNA synthesis and repair. It is often utilized as an adjuvant therapy for certain infections and chemotherapeutic agents.

5 Must Know Facts For Your Next Test

1. Folinic acid can be used in combination with antifungal medications to enhance their efficacy.
2. It plays a crucial role in rescuing normal cells from the toxic effects of methotrexate, which is sometimes used to treat fungal infections of the nervous system.
3. Folinic acid does not require enzymatic conversion to be active, unlike folic acid.
4. It can help mitigate side effects related to antifolate drugs used in treating parasitic diseases affecting the nervous system.
5. Patients with severe fungal or parasitic infections of the nervous system may receive folinic acid as part of their treatment regimen to support immune function.

Review Questions

• What role does folinic acid play in combination with antifungal medications?
• How does folinic acid differ from folic acid in terms of metabolic activation?
• Why might folinic acid be included in a treatment regimen for parasitic diseases affecting the nervous system?

Related terms

Methotrexate: A chemotherapy agent and immune system suppressant that can also be used against certain infections.

Antifolate Drugs: Medications that inhibit the action of folates, essential for DNA synthesis and cell division.

Leucovorin Rescue: The use of leucovorin (folinic acid) to protect normal cells from the toxicity of methotrexate.