Fluconazole

Definition

Fluconazole is an antifungal medication used to treat various fungal infections. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.

5 Must Know Facts For Your Next Test

1. Fluconazole is commonly used to treat Candida infections, including those affecting the mouth, throat, and genitals.
2. It is effective against cryptococcal meningitis, a severe fungal infection of the nervous system.
3. Fluconazole can be administered orally or intravenously depending on the severity and location of the infection.
4. Unlike some other antifungal medications, fluconazole has good penetration into cerebrospinal fluid, making it useful for treating central nervous system infections.
5. Resistance to fluconazole can occur, especially in immunocompromised patients or with prolonged use.

Review Questions

• What major mechanism does fluconazole use to combat fungal infections?
• Which types of fungal infections are commonly treated with fluconazole?
• Why is fluconazole particularly effective for treating central nervous system infections?

Related terms

Ergosterol: A key component of fungal cell membranes targeted by antifungal drugs like fluconazole.

Candida: A genus of yeast that causes various infections treated by fluconazole.

Cryptococcal Meningitis: A serious infection caused by Cryptococcus fungi that affects the brain and spinal cord.