Fecal transplant

Definition

A fecal transplant involves the transfer of stool from a healthy donor into the gastrointestinal tract of a recipient. This procedure is primarily used to treat recurrent Clostridioides difficile infections.

5 Must Know Facts For Your Next Test

1. Fecal transplants help restore the balance of gut microbiota disrupted by bacterial infections.
2. The most common indication for fecal transplantation is recurrent Clostridioides difficile infection, which fails to respond to standard antibiotic treatments.
3. Fecal transplants can be administered via colonoscopy, enema, or capsules containing freeze-dried material.
4. Clinical trials are exploring the efficacy of fecal transplants in treating other conditions such as inflammatory bowel disease and irritable bowel syndrome.
5. Donor screening is critical to prevent the transmission of infectious agents during a fecal transplant.

Review Questions

• What is the primary medical indication for conducting a fecal transplant?
• Name at least two methods through which fecal material can be administered in a fecal transplant.
• Why is donor screening important in the process of performing a fecal transplant?

Related terms

Clostridioides difficile: A bacterium that causes severe diarrhea and colitis, often following antibiotic use.

Microbiota: The community of microorganisms living in a particular environment, such as the human gut.

Colonoscopy: A medical procedure that uses a long, flexible camera to inspect the interior lining of the colon.