ESKAPE pathogens

Definition

ESKAPE pathogens are a group of bacteria known for their high rates of antibiotic resistance and propensity to cause hospital-acquired infections. The acronym stands for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.

5 Must Know Facts For Your Next Test

1. ESKAPE pathogens are responsible for the majority of nosocomial (hospital-acquired) infections.
2. These bacteria have developed mechanisms to evade the effects of multiple antibiotics, making treatment difficult.
3. Common resistance mechanisms include the production of beta-lactamases, efflux pumps, and biofilm formation.
4. Infections caused by ESKAPE pathogens result in higher morbidity and mortality rates compared to non-resistant bacterial infections.
5. Efforts to combat these pathogens involve the development of new antimicrobial agents and alternative therapies.

Review Questions

• What does the acronym ESKAPE stand for?
• Why are ESKAPE pathogens particularly concerning in healthcare settings?
• Name at least two resistance mechanisms commonly seen in ESKAPE pathogens.

Related terms

Antibiotic Resistance: The ability of bacteria to survive and proliferate despite the presence of antibiotic drugs.

Nosocomial Infection: An infection acquired in a hospital or healthcare facility setting.

Beta-lactamase: An enzyme produced by certain bacteria that breaks down beta-lactam antibiotics, rendering them ineffective.