Collagenase

Definition

Collagenase is an enzyme produced by certain bacteria that breaks down collagen, a major structural protein in connective tissues. This enzymatic activity aids in the spread of infection by degrading host tissue barriers.

5 Must Know Facts For Your Next Test

1. Collagenase is crucial for the virulence of some bacterial pathogens as it facilitates tissue invasion and dissemination.
2. In respiratory infections, collagenase can degrade the extracellular matrix, allowing bacteria to penetrate deeper into tissues.
3. Pseudomonas aeruginosa and Clostridium perfringens are examples of bacteria that produce collagenase.
4. Inhibiting collagenase activity can be a therapeutic strategy to prevent bacterial spread in infections.
5. The presence of collagenase increases bacterial pathogenicity by compromising host immune defenses.

Review Questions

• What role does collagenase play in bacterial pathogenicity?
• Name two bacterial species known to produce collagenase.
• How does collagenase facilitate the spread of respiratory infections?

Related terms

Virulence Factor: A molecule produced by pathogens that contributes to the pathogenicity and enables them to colonize a host.

Extracellular Matrix: A network of proteins and other molecules outside cells that provide structural support to tissues.

Pseudomonas aeruginosa: A common gram-negative bacterium known for its resistance to antibiotics and production of various virulence factors, including collagenase.