Carbapenemase

Definition

Carbapenemase is an enzyme produced by certain bacteria that hydrolyzes carbapenem antibiotics, rendering them ineffective. This mechanism contributes significantly to antibiotic resistance.

5 Must Know Facts For Your Next Test

1. Carbapenemase-producing organisms are often resistant to multiple classes of antibiotics, not just carbapenems.
2. Klebsiella pneumoniae carbapenemase (KPC) is one of the most common types of carbapenemases.
3. Detection of carbapenemase production can be performed using methods such as the Modified Hodge Test and polymerase chain reaction (PCR).
4. The presence of carbapenemases in bacteria is often associated with high morbidity and mortality in clinical settings.
5. Effective infection control measures are crucial to prevent the spread of carbapenemase-producing bacteria.

Review Questions

• What is the primary function of a carbapenemase enzyme?
• Name one common type of carbapenemase found in clinical isolates.
• What are two methods used to detect carbapenemase production in bacteria?

Related terms

Antibiotic Resistance: The ability of bacteria to withstand the effects of an antibiotic.

Modified Hodge Test: A phenotypic method used to detect carbapenemase production in bacteria.

Klebsiella pneumoniae: A type of Gram-negative bacterium that often produces carbapenemases.