Allylamines

Definition

Allylamines are a class of antifungal drugs that inhibit the enzyme squalene epoxidase, which is crucial for ergosterol synthesis in fungal cell membranes. They are effective against dermatophytes and some yeast infections.

5 Must Know Facts For Your Next Test

1. Allylamines primarily target the enzyme squalene epoxidase.
2. They disrupt ergosterol synthesis, leading to fungal cell membrane instability.
3. Common examples include terbinafine and naftifine.
4. They are particularly effective against dermatophyte infections such as athlete's foot and ringworm.
5. Allylamines can be administered both topically and orally.

Review Questions

• What enzyme do allylamines inhibit?
• Which type of infections are allylamines most effective against?
• Name two common allylamines used in clinical practice.

Related terms

Ergosterol: A crucial component of fungal cell membranes.

Squalene Epoxidase: An enzyme targeted by allylamines, essential for ergosterol synthesis.

Terbinafine: A common allylamine antifungal drug used to treat dermatophyte infections.