logP, or the logarithm of the partition coefficient (P), is a measure of a compound's hydrophobicity, reflecting its tendency to distribute between a hydrophobic solvent (like octanol) and a hydrophilic solvent (like water). This value is crucial in understanding how well a drug can permeate biological membranes, influencing absorption, distribution, metabolism, and excretion (ADME) properties of pharmaceuticals.
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