Synaptic weakening refers to the process by which the strength of synaptic connections between neurons is decreased, often resulting in reduced neurotransmission efficiency. This phenomenon is a critical aspect of synaptic plasticity, balancing the mechanisms of long-term potentiation (LTP) that enhance synaptic strength. Synaptic weakening is primarily associated with long-term depression (LTD), which helps in refining neural circuits and is essential for learning and memory processes.
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