Hasselbalch
from class:
Intro to Chemistry
Definition
Hasselbalch refers to the Henderson-Hasselbalch equation, which relates the pH of a solution to the pKa and the ratio of the concentrations of its conjugate acid-base pair. It is used to estimate the pH in buffer solutions.
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5 Must Know Facts For Your Next Test
- The Henderson-Hasselbalch equation is written as $\text{pH} = \text{pKa} + \log \left( \frac{[A^-]}{[HA]} \right)$.
- It helps in calculating the pH of buffer solutions by providing a relationship between pH, pKa, and the concentrations of acid and conjugate base.
- The equation assumes that the activity coefficients are equal, which is a good approximation for dilute solutions.
- It can be used to determine the required ratio of conjugate base to acid for a desired pH.
- This equation is crucial in designing buffers with specific pH values necessary for various chemical and biological processes.
Review Questions
- How does the Henderson-Hasselbalch equation relate pH, pKa, and concentrations of acid and base?
- What assumptions are made when using the Henderson-Hasselbalch equation?
- Why is the Henderson-Hasselbalch equation important in preparing buffer solutions?
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