Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where the body's immune system mistakenly attacks healthy tissues, leading to widespread inflammation and damage to various organs. This condition highlights the breakdown of immune tolerance, as the body fails to distinguish between self and non-self antigens, resulting in the production of autoantibodies that target its own cells. SLE can manifest in a variety of ways, making it a complex disease that encompasses multiple symptoms and organ systems.
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