Sertoli cells

Definition

Sertoli cells are specialized cells found within the seminiferous tubules of the testes. They play a crucial role in nurturing and supporting the development of sperm cells.

5 Must Know Facts For Your Next Test

1. Sertoli cells create a blood-testis barrier that protects developing sperm from harmful substances.
2. They secrete androgen-binding protein, which helps maintain high levels of testosterone necessary for spermatogenesis.
3. Sertoli cells phagocytize residual cytoplasm during spermiogenesis, aiding in the maturation of sperm.
4. They produce inhibin, a hormone that regulates the release of follicle-stimulating hormone (FSH) from the pituitary gland.
5. Sertoli cells provide structural support and nutrients to developing germ cells throughout spermatogenesis.

Review Questions

• What function does the blood-testis barrier formed by Sertoli cells serve?
• How do Sertoli cells contribute to the regulation of spermatogenesis?
• What hormone is produced by Sertoli cells that influences FSH levels?

Related terms

Leydig Cells: Specialized cells in the testes that produce testosterone.

Spermatogenesis: The process by which sperm are produced in the testes.

Follicle-Stimulating Hormone (FSH): A hormone involved in regulating reproductive processes, including spermatogenesis and oocyte maturation.