The serotonin transporter (SERT) is a protein that plays a crucial role in the reuptake of serotonin from the synaptic cleft back into presynaptic neurons. This process is essential for regulating serotonin levels in the brain, influencing mood, emotion, and various cognitive functions. By controlling serotonin availability, the serotonin transporter significantly impacts synaptic transmission and plasticity, which are fundamental to how neurons communicate and adapt.
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