Gastric inhibitory peptide

Definition

Gastric inhibitory peptide (GIP) is a hormone produced by the small intestine that inhibits gastric motility and secretion of gastric acid. It also stimulates insulin secretion in response to food intake.

5 Must Know Facts For Your Next Test

1. GIP is secreted by the K cells in the duodenum and jejunum.
2. It plays a role in decreasing the release of stomach acid, helping to regulate the digestive process.
3. GIP is part of the incretin family, hormones that help regulate insulin levels.
4. The primary stimuli for GIP release are fats and glucose in the small intestine.
5. High levels of GIP can contribute to obesity and insulin resistance.

Review Questions

• Where is GIP secreted and what triggers its release?
• What are two main functions of GIP in the digestive system?
• How does GIP affect insulin secretion?

Related terms

Cholecystokinin (CCK): A hormone that stimulates digestion of fat and protein by triggering the release of digestive enzymes from the pancreas and bile from the gallbladder.

Secretin: A hormone released by the small intestine that stimulates the pancreas to secrete bicarbonate, neutralizing stomach acid entering the small intestine.

Incretins: A group of metabolic hormones that stimulate a decrease in blood glucose levels by increasing insulin secretion.