Elastase

Definition

Elastase is a proteolytic enzyme that breaks down elastin, an important protein in connective tissue. It is primarily secreted by the pancreas and plays a crucial role in the digestive process.

5 Must Know Facts For Your Next Test

1. Elastase is produced by the pancreas and released into the small intestine.
2. It specifically targets and hydrolyzes elastin, a protein found in connective tissues.
3. Elastase functions optimally at an alkaline pH, typically found in the small intestine.
4. Inhibitors of elastase can be used to treat conditions where excessive degradation of elastin occurs, such as emphysema.
5. Deficiencies or malfunctions of elastase can lead to digestive issues and complications in nutrient absorption.

Review Questions

• What type of macromolecule does elastase break down during digestion?
• Where is elastase produced and where does it perform its function?
• Why are inhibitors of elastase clinically significant?

Related terms

Trypsin: A proteolytic enzyme that breaks down proteins into smaller peptides in the small intestine.

Chymotrypsin: Another pancreatic enzyme that hydrolyzes peptide bonds, aiding in protein digestion.

Lipase: An enzyme produced by the pancreas that catalyzes the breakdown of fats into fatty acids and glycerol.