Cytogenetic mapping

Definition

Cytogenetic mapping involves locating specific genes on a chromosome using microscopic techniques. It combines cytology and genetics to create a visual representation of chromosomal features and gene positions.

5 Must Know Facts For Your Next Test

1. Cytogenetic maps use banding patterns produced by staining techniques to identify gene locations.
2. These maps are crucial for identifying chromosomal abnormalities linked to genetic disorders.
3. Fluorescence in situ hybridization (FISH) is a common method used in cytogenetic mapping.
4. The resolution of cytogenetic maps is lower compared to physical and genetic maps, often in the range of several megabases.
5. Cytogenetic mapping provides a visual reference that complements molecular data from other genome mapping techniques.

Review Questions

• What microscopic technique is commonly used in cytogenetic mapping?
• How do cytogenetic maps differ from physical maps in terms of resolution?
• Why are cytogenetic maps important for identifying genetic disorders?

Related terms

Fluorescence in situ Hybridization (FISH): A technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes.

Genetic Mapping: The process of determining the location and chemical sequence of specific genes on chromosomes.

Physical Mapping: A type of genome mapping that uses molecular biology techniques to determine the physical distance between genes or genetic markers.