Zinc finger nucleases (ZFNs) are engineered proteins that facilitate targeted DNA modification by combining a zinc finger DNA-binding domain with a FokI nuclease domain. They allow for precise editing of the genome by creating double-strand breaks at specific sites, which can then be repaired through natural cellular mechanisms or homology-directed repair, thus enabling gene knockout, insertion, or correction.
congrats on reading the definition of zinc finger nucleases. now let's actually learn it.