Phosphatidylserine exposure refers to the process where phosphatidylserine, a phospholipid normally located on the inner leaflet of the plasma membrane, becomes externalized to the outer surface of the cell membrane. This event is a key indicator of apoptosis, as it serves as an 'eat me' signal for phagocytic cells, prompting their recognition and engulfment of dying cells. The movement of phosphatidylserine to the cell surface is mediated by various mechanisms, including the activation of scramblases and the inactivation of flippases during programmed cell death.
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