The Hill coefficient is a numerical value that quantifies the degree of cooperativity exhibited by a ligand when binding to a multi-subunit protein or enzyme. This coefficient helps to understand how the binding of one ligand affects the binding of additional ligands, revealing insights into allosteric regulation and the functionality of proteins. A Hill coefficient greater than one indicates positive cooperativity, while a value less than one suggests negative cooperativity, allowing for a clearer picture of how proteins interact with their ligands under various conditions.
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