💊Pharmacology for Nurses Unit 37 – Transgender and Nonbinary Drugs

Key Concepts and Terminology

• Transgender refers to individuals whose gender identity differs from the sex assigned at birth
• Nonbinary is an umbrella term for gender identities that are not exclusively male or female
• Gender dysphoria is the distress experienced due to the incongruence between one's gender identity and assigned sex
• Hormone therapy involves the use of hormones to align physical characteristics with gender identity
• Feminizing hormone therapy aims to develop feminine characteristics in transgender women
• Masculinizing hormone therapy aims to develop masculine characteristics in transgender men
• Gender-affirming surgery includes procedures to modify physical characteristics to align with gender identity
• Cisgender refers to individuals whose gender identity aligns with their assigned sex at birth

Hormone Therapy Basics

• Hormone therapy is a cornerstone of medical transition for many transgender individuals
• Goals of hormone therapy include aligning physical characteristics with gender identity and reducing gender dysphoria
• Hormone therapy is typically initiated after a comprehensive evaluation by a healthcare provider experienced in transgender care
• Informed consent involves discussing the risks, benefits, and expectations of hormone therapy with the patient
• Hormone levels are monitored regularly to ensure they are within the target range for the desired effects
• Adjustments to hormone dosages may be necessary based on individual response and side effects
• Hormone therapy is often a lifelong treatment for transgender individuals
  • Regular follow-up with a healthcare provider is essential to monitor therapy and address any concerns

Feminizing Medications

• Estradiol is the primary feminizing hormone used in transgender women
  • Estradiol can be administered orally, transdermally (patches), or by injection
• Anti-androgens are used to block the effects of testosterone and promote feminization
  • Spironolactone is a commonly used anti-androgen that blocks testosterone receptors and reduces testosterone production
  • Cyproterone acetate is another anti-androgen that suppresses testosterone production and has progestogenic effects
• Progesterone may be used in some cases to enhance breast development and mood stability
• Feminizing effects of hormone therapy include breast development, redistribution of body fat, softening of skin, and decreased facial/body hair growth
• It may take several months to years for the full effects of feminizing hormone therapy to be achieved
• Feminizing hormone therapy does not typically affect pitch of voice, which may require voice therapy or surgery

Masculinizing Medications

• Testosterone is the primary masculinizing hormone used in transgender men
  • Testosterone can be administered by injection, transdermal gel/patches, or implanted pellets
• Testosterone promotes the development of masculine characteristics, such as deepening of voice, facial/body hair growth, and increased muscle mass
• Menstrual suppression is often desired by transgender men and can be achieved through testosterone therapy or progestin-only medications
• Masculinizing effects of hormone therapy include redistribution of body fat, increased muscle mass, enlargement of the clitoris, and increased libido
• Testosterone therapy may cause vaginal atrophy and dryness, which can be managed with topical estrogen or lubricants
• Testosterone therapy does not typically result in significant breast tissue reduction, which may require surgical intervention (mastectomy)

Side Effects and Monitoring

• Common side effects of feminizing hormone therapy include breast tenderness, decreased libido, mood changes, and weight gain
  • Rare but serious risks include venous thromboembolism, liver dysfunction, and prolactinoma
• Common side effects of masculinizing hormone therapy include acne, male pattern baldness, weight gain, and mood changes
  • Rare but serious risks include polycythemia, liver dysfunction, and sleep apnea
• Regular monitoring of hormone levels, liver function, lipid profile, and blood pressure is essential
• Bone mineral density should be monitored, especially in individuals with risk factors for osteoporosis
• Screening for breast cancer and cervical cancer should be performed as per guidelines for the assigned sex at birth
• Mental health should be assessed regularly, as hormone therapy may impact mood and well-being

Drug Interactions and Contraindications

• Estrogen therapy may interact with medications that affect liver enzymes, such as rifampin and certain anticonvulsants
• Testosterone therapy may interact with anticoagulants, increasing the risk of bleeding
• Hormone therapy may affect the metabolism of other medications, requiring dose adjustments
• Estrogen therapy is contraindicated in individuals with a history of estrogen-sensitive cancers, such as breast cancer
• Testosterone therapy is contraindicated in individuals with prostate cancer or severe benign prostatic hyperplasia
• Hormone therapy should be used with caution in individuals with cardiovascular disease, liver disease, or thromboembolic disorders

Special Considerations for Nonbinary Patients

• Nonbinary individuals may desire a combination of feminizing and masculinizing effects or may opt for lower doses of hormones
• Goals of hormone therapy for nonbinary individuals may vary and should be discussed on an individual basis
• Nonbinary individuals may face unique challenges in accessing gender-affirming care due to lack of provider understanding or binary-centric healthcare systems
• Pronouns and gender-neutral language should be used as per the individual's preference
• Nonbinary individuals may require additional support in navigating social and legal aspects of their gender identity

Nursing Implications and Patient Education

• Nurses play a crucial role in providing education and support to transgender and nonbinary patients undergoing hormone therapy
• Patients should be informed about the expected effects, timeline, and potential side effects of hormone therapy
• Patients should be encouraged to adhere to the prescribed hormone regimen and attend regular follow-up appointments
• Nurses should assess for signs of complications, such as venous thromboembolism or liver dysfunction
• Patients should be educated on the importance of regular health screenings, such as breast cancer and cervical cancer screening
• Nurses should provide a non-judgmental and inclusive environment, using the patient's preferred name and pronouns
• Patients should be referred to mental health professionals and support groups as needed
• Nurses should advocate for the healthcare needs of transgender and nonbinary patients and promote cultural competence within the healthcare team