Radiobiology
Checkpoint activation is a crucial cellular process that regulates the progression of the cell cycle in response to DNA damage, ensuring that cells do not divide with unprepared or damaged DNA. This process involves the detection of DNA lesions and the activation of signaling pathways that halt the cell cycle, allowing for repair mechanisms to correct any damage before proceeding. By coordinating DNA repair and cell cycle control, checkpoint activation plays a key role in maintaining genomic stability and preventing the propagation of mutations caused by radiation or other damaging agents.
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