Zocor

Definition

Zocor, also known as simvastatin, is a lipid-lowering medication that inhibits HMG-CoA reductase. It is primarily used to reduce cholesterol levels and prevent cardiovascular disease.

5 Must Know Facts For Your Next Test

1. Zocor is part of the statin class of drugs, which lower cholesterol by inhibiting the enzyme HMG-CoA reductase.
2. The primary effect of Zocor is to decrease LDL cholesterol levels and modestly increase HDL cholesterol.
3. Common side effects include muscle pain, digestive problems, and increased liver enzymes.
4. Patients taking Zocor should avoid grapefruit juice as it can increase the drug's concentration in the blood.
5. Zocor is often prescribed alongside lifestyle changes such as diet and exercise for maximum efficacy.

Review Questions

• What enzyme does Zocor inhibit to lower cholesterol levels?
• List two common side effects associated with Zocor.
• Why should patients taking Zocor avoid grapefruit juice?

Related terms

Statins:

A class of drugs that lower cholesterol by inhibiting HMG-CoA reductase.

HMG-CoA Reductase Inhibitors: Drugs that block the action of HMG-CoA reductase in the liver, thereby reducing cholesterol production.

PCSK9 Inhibitors:

A newer class of drugs that lower LDL cholesterol by increasing the number of LDL receptors available to clear LDL from the blood.