Vomiting center (VC)

Definition

The vomiting center (VC) is a neural network located in the medulla oblongata of the brainstem that coordinates the act of vomiting. It integrates signals from various sources to trigger and control emesis.

5 Must Know Facts For Your Next Test

1. The VC receives input from the chemoreceptor trigger zone (CTZ), vestibular system, gastrointestinal tract, and higher brain centers.
2. Neurotransmitters like serotonin, dopamine, acetylcholine, and histamine play crucial roles in activating the VC.
3. Antiemetic drugs often target neurotransmitter receptors involved in the VC signaling pathway to prevent or reduce vomiting.
4. Activation of the VC can result from various stimuli including toxins, motion sickness, and psychological factors.
5. The VC coordinates with other brain regions to manage both the physical act of vomiting and associated symptoms like nausea.

Review Questions

• What are the main sources of input that influence the vomiting center?
• Which neurotransmitters are primarily involved in activating the vomiting center?
• How do antiemetic drugs typically work to reduce or prevent vomiting?

Related terms

Chemoreceptor Trigger Zone (CTZ): A region in the area postrema that detects bloodborne toxins and communicates with the VC.

Antiemetics:

Drugs designed to prevent or alleviate nausea and vomiting by targeting different pathways including those involving the VC.

Serotonin Receptors: Receptors that bind serotonin; antagonists at these receptors can help reduce nausea and vomiting.